Translational control of intron splicing in eukaryotes
نویسندگان
چکیده
منابع مشابه
Translational Control across Eukaryotes
Diversity is one of the most significant features of life. The current assessment of biodiversity on Earth reaches several millions of living species, and an unimaginable number of species that have gone extinct. Further more, diversity is ingrained in all aspects of life, namely, genetics, metabolic needs, cell complexity, body plans and organismal morphology , developmental programs, behavior...
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As obligate intracellular parasites, viruses rely exclusively on the translational machinery of the host cell for the synthesis of viral proteins. This relationship has imposed numerous challenges on both the infecting virus and the host cell. Importantly, viruses must compete with the endogenous transcripts of the host cell for the translation of viral mRNA. Eukaryotic viruses have thus evolve...
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Biochemical and genetic studies are revealing a network of interactions between eukaryotic translation initiation factors, further refining or redefining perceptions of their function. The notion of translated mRNA as a 'closed-loop' has gained support from the identification of physical and functional interactions between the two mRNA ends and their associated factors. Translational control me...
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Alternative splicing is regulated in part by variations in the relative concentrations of a variety of factors, including serine/arginine-rich (SR) proteins. The SR protein SC35 self-regulates its expression by stimulating unproductive splicing events in the 3' untranslated region of its own pre-mRNA. Using various minigene constructs containing the terminal retained intron and flanking exons, ...
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Numerous databases of alternative splice forms have been generated over the recent years, which – beside of using heterogenous input data – differ substantially in the definition and in the representation of patterns. Motivated by this, we have developed a novel relative position notation system to univocally describe alternative splicing (AS) events, and a parsing and visualization tool (AStaL...
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ژورنال
عنوان ژورنال: Nature
سال: 2008
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature06495